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Volume 6 Issue 5 (May, 2018)

Original Articles

Evaluation of efficacy of Oral Labetalol and Oral Nifedipine in hypertensive disorders of pregnancy: A comparative study
Anjali Agraj Gupta, Arpita Goen

Background: Hypertensive disorders are the most common medical disorders encountered during pregnancy and are responsible for 31% of the maternal deaths in India. Hence; the present study was undertaken for evaluation of efficacy of Oral Labetalol and Oral Nifedipine in hypertensive disorders of pregnancy. Materials & methods: A total of 60 patients were enrolled. Only those patients were enrolled which were prescribed with either Labetalol or Nifedipine were selected and included in the study. Preterm or term pregnant women with severe preeclampsia/ eclampsia and BP ≥160/100 mm Hg were included in the study. Complete demographic and clinical details of all the patients were obtained. Patients were divided into 2 groups of 30 each. Group A patients were given oral labetalol and group B were given oral 10 mg Nifedipine. Maternal blood pressure was measured. Neonatal outcome was assessed. Results: Among the patients of group A, 15 patients were of primi gravida while 10 patients were of G2. Among the patients of group B, 16 patients were of primi gravida while 9 patients were of G2. Mean Prolongation in duration among subjects of group A and group B was 126.5 hours and 153.2 hours respectively. Among the patients of Nifedipine group, death occurred in 1 patient while among the patients of the labetalol group, death occurred in 2 patients. Conclusion: From the above results, the authors conclude that Oral Nifedipine was better in comparison to labetalol. Key words: Oral Labetalol, Nifedipine

 
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