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Volume 5 Issue 6 (June, 2017)

Original Articles

An analytic study of biomarkers in allergic diseases and asthma
Aswath Kumar, Jyothi Aswath Kumar, Atish Kiran

Background: Asthma is a heterogeneous disease diagnosed by the presence of intermittent symptoms of wheeze, cough and chest tightness, typically related to a reversible airflow obstruction, usually resolves spontaneously or with asthma treatment. The present study was conducted to assess biomarkers in asthma and allergic diseases. Materials & Methods: 56 patients of asthma and allergic diseases was included. Submucosal or transbronchial bronchial biopsies were obtained from all patients. Assessment of Eosinophil, Eosinophil cationic protein (ECP) and Lipoxins A4 was performed. Results: out of 56 patients, males were 36 and females were 20. The mean eosinophil level in group I was 300.6 cells/μL and in group II was 4.5 cells/μL, ECP level was 24.6 in group I µg/L and 114.5 µg/L in group II and lipoxins A4 level was 1.8 ng/mL in group I and 0.4 in group II ng/mL. The difference was significant (P< 0.05). Conclusion: The level of biomarkers was increased in patients with asthma and allergic diseases as compared to healthy subjects. Key words: Asthma, biomarkers, ECP.

 
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