Journal of AdvancedMedical and Dental Sciences Research

Background: The present study was conducted to determine the effect of oral solifenacin succinate in glaucoma paradox during overactive bladder treatment. Materials & Methods: The present study was conducted on 60 patients of overactive bladder and 40 healthy females. Patients were divided into 2 groups. Group I were given oral 5 mg solifenacin succinate/day. Group II comprised of urogynecologically healthy age-matched consecutive subjects with no history of ocular disease. Fundus examination using a 90-diopter lens was performed in all subjects on day 0 and 30th. Results: The mean IOP on day 0 in group I was 16.46 mm Hg and in group II was 15.30 mm Hg and on 31st day was 16.42 mm Hg and 15.72 mm Hg in group I and II respectively. The difference was non- significant (P< 0.05). Conclusion: Authors found that treatment with solifenacin succinate in females with OAB had no clinically significant effect on intraocular pressure values Key words: Anticholinergics, Glaucoma, Solifenacin succinate.