Background: The present study is hospital based observational study was undertaken in Department of Medicine, N.S.C.B. MCH Jabalpur from March 2015 - August 2016. Method: Present study includes 100 patients of type 2 diabetes mellitus with abnormal fasting lipid profile (one or more lipid parameter) of which 49 are males and 51 females. Results: On applying paired t test in between mean of fasting and postprandial lipid parameters of patients we found that there was significant increase in SCH, LDL, VLDL, Triglycerides, SCH/HDL ratio in Postprandial state as compared to fasting state, p value was <0.05 while there was no significance found in mean value of HDL (P >0.05). Conclusion: Diabetes is one of the leading health problems in modern world. Diabetic dyslipidemia contributes to excess morbidity and mortality in Type 2 diabetes mellitus and the abnormal lipid profile in postprandial state is more significant than lipid profile in fasting state as most in causing atherosclerotic complications. Atherosclerosis is a postprandial phenomenon with respect to lipids, as we are in the postprandial phase for most of the day, with an additional adverse effect of the meal induced hyperglycemia. Thus correction in early phase can prevent complications. So in routine practice PP lipid profile along with fasting is warranted.
Keywords: Fasting, Postprandial Lipid Abnormality, DM type 2