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Volume 8 Issue 9 (September, 2020)
Original Articles
Different treatment modalities of BRONJ- Our clinical experience | |
Sumera Gul, Jahangir Dar, Ajaz A Shah, Samah Bashir, Najma Banoo | |
The mechanism of action of bisphosphonates (BPs) is not yet well understood, but it essentially involves a powerful inhibition of bone resorption as a result of the reduction of osteoclast activity; as far as nitrogen-containing BPs are concerned they are also thought to have antiangiogenic effects. Osteonecrosis of the jaws has recently emerged as a significant complication in a subset of patients receiving these drugs. Based on a growing number of case reports and institutional reviews, bisphosphonate therapy may cause exposed and necrotic bone that is isolated to the jaw. Treatment with bisphosphonate drugs is associated with several complications including renal and gastrointestinal side effects, particularly oesophageal ulceration, but the most serious is that of osteonecrosis of the jaw (bisphosphonate-related osteonecrosis of the jaw – BRONJ). Key words: Bisphosphonates, Necrosis, Jaws |
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