Volume 8 Issue 9 (September, 2020)

Original Articles

Optimization of methods for prevention and intensive therapy of complications in pregnant women with chronic syndrome of Disseminated Intravascular Coagulation
Feruz Yusufovich Nazarov, Suvon Totliboevich Yarmatov

In order to develop preventive intensive care methods that ensure safe delivery in women with chronic disseminated intravascular coagulation syndrome and thus have a beneficial effect on the condition of the mother and fetus, we analyzed exchange cards and the birth history of 45 pregnant women. All pregnant women underwent intensive therapy including β-blockers (atenalol, bisoprolol, metaprolol), Ca antagonists (nifedipine, amlodipine, corinfar), magnesium therapy, neurometabolic protection if necessary, as well as infusion therapy (refortan, stabizol, etc.). Pregnant women of the main group received enoxaparin and heparin in a complex of intensive care. All patients showed a decrease in platelet count by 44%, a decrease in prothrombin index by 47%, prolongation of prothrombin time, clotting time, and an increase in hemoglobin values by 27%. In all pregnant women, the coagulogram was studied in stages: before delivery, day 1, day 3 and day 5. According to the literature and our research, in the third trimester during physiological pregnancy, there is an increase in the total activity of blood coagulation factors that make up the internal pathway of hemostasis activation - VIII, IX, X, XI, XII. All patients underwent elective delivery. In 6 patients (26%) of the main group, the clotting time was lengthened by 34% during the genus, in the rest of the patients it did not change. No complications were observed during childbirth and early postpartum. The use of enoxaparin and heparin in a complex of intensive therapy reduces the risk of developing fatal complications, disseminated intravascular coagulation of the syndrome in risk groups of pregnant women, and also improves indicators of the quality of life of the mother and the condition of the fetus. Key words: Disseminated intravascular coagulation syndrome, pregnancy, bleeding.

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