Journal of AdvancedMedical and Dental Sciences Research

Background: Diabetes mellitus is a heterogeneous group of disease, resulting from a diversity of etiologies, genetic and environmental factors acting jointly. Aim: To study the scenario of central obesity in newly diagnosed patients of Kashmir valley. Materials and methods: This study was performed to evaluate central obesity in newly diagnosed T2DM patients and healthy controls of Kashmiri population. Study was conducted in the Department of Biochemistry, Govt. Medical College Srinagar. A total of 180 subjects were enrolled for study from OPD/IPD Department of Medicine, GMC, Srinagar. 100 T2DM patients were included in the study and were diagnosed according to ADA criteria and 80 normal age and sex matched healthy individuals were taken as controls. Dietary pattern, lifestyle, anthropometric parameters were documented after proper questionnaire. Results: There was increase in all 3 parameters in patients compared to controls and was strongly statistically significant (p<0.05). There was highly significant increase in TG, LDL & cholesterol levels in patients compared to controls, whereas HDL level decreased significantly and VLDL increased significantly in diabetic patients as compared to healthy controls. The glycemic profile (Glucose Fasting mg/dl and HbA1c %) and BMI in T2DM cases was higher as compared to healthy controls and found stastically significant (P<0.05). Conclusion: It can be concluded from this study that central obesity may be taken one of the reason to cause type 2 diabetes in new individuals and these patients are more prone to dyslipidaemia and HbA1c can be used as an indirect indicator of dyslipidaemia in type 2 diabetes in addition to as glycemic control biomarker. Thus early diagnosis of dyslipidaemia and central obesity can be used as a preventive measure for development of type 2 diabetes mellitus and other diseases like cardiovascular disease (CVD). Patients should be educated about regular monitoring of lipid profiles and if found to be abnormal, should control blood glucose and cholesterol very effectively and people should also educated about regular exercise to avoid central obesity so that T2DM should be minimized worldwide.