Journal of AdvancedMedical and Dental Sciences Research

Introduction: Platelet-rich plasma (PRP) is an autologous concentration of human platelets in a small volume of plasma. Because it is a concentration of platelets, it is also a concentration of the 7 fundamental protein growth factors proved to be actively secreted by platelets to initiate all wound healing. The aims of this narrative review were: i) to describe the different uses of PRP in dental surgery and oral surgery; and ii) to discuss its efficacy, efficiency and risk/ benefit ratio. Materials & Method: Study sample included 30 patients requiring bilateral mandibular 3rd molars extraction, all patients underwent bilateral removal of 3rd molars and PRP that was prepared prior to start of the procedure was activated to form PRP gel which was placed into one of the extraction socket selected by the author. All patients were recalled on day 1, day 3, day 7, 2months, 3months, and 4 months, postoperatively for follow-up study. Results: There were 15 male subjects and 15 female subjects who had participated in the study. At 16 weeks: blending of bone seen in all 30 patients in both PRP (study) site & NONPRP (control) site. Trabecular bone formation also seen in all 30 patients in both the sites. Assessment of bone density (gray level value) at 16 weeks shows, the average gray scale value for PRP (study) site (136.9) was comparatively higher than NON PRP(control) site(113). Conclusion: The study clearly indicates a definite improvement in the soft tissue healing and faster regeneration of bone after third molar surgery in cases treated with PRP as compared to the control group post operatively. This improvement in the wound healing, decrease in pain, and increase in the bone density signifies and highlights the use of PRP, certainly as a valid method in inducing and accelerating soft and hard tissue regeneration. The procedure of PRP preparation is simple, cost effective and has demonstrated good results. Key words: Plasma rich protein, third molar extraction, osseous regeneration.