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Volume 8 Issue 4 (April, 2020)

Original Articles

Role of Zinc in Febrile Seizure
Gaurav Kumar Sharma, Anil Kumar Chaudhary, Upendra Prasad Sahu

Background: 3 to 5% of children below 5 yrs experience febrile seizure. Zinc has been studied in pathophysiology of febrile seizure. The objective of this study was to compare the serum zinc levels in children with febrile seizure, fever without seizure and in healthy children. Methods: The present study was a cross sectional study in which a total of 75 children aged 6 months to 5 years meeting the inclusion criteria were included. The study comprised of 3 groups - Group A: Children with febrile seizures (25 cases), Group B: Children with fever, but no seizures (25 cases) and Group C: Healthy children (25 cases). Serum zinc was determined and compared statistically among these groups. Results: There was no significant difference in sex, age, weight, height, temperature at admission and head circumference in the three groups (P >0.05). Mean serum zinc level was 48.58 ± 14.86 µgm/dl in group A, 62.64 ± 16.79 µgm/dl in group B and 84.90 ± 19.86 in Group C . Zinc level was least in febrile seizure group than group B and maximum in group C. Conclusions: This study shows that serum zinc levels are decreased in children with febrile seizures which were found to be statistically significant.The level of zinc plays a vital role in the pathogenesis of febrile seizures Key words: Febrile seizure, Serum zinc level, Fever.

 
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