Volume 8 Issue 2 (February, 2020)

Review Articles

Effects of Vaping on Periodontium - A Review
Shazia Kazi, Anas Abdul Khader, Ami Mayurkumar Sheth, Mohasin Abdul Khader, Mukhatar Ahmed Javali, Arundhati Pramod Hinge, Pritee Rajkumar Pandey

The electronic-cigarettes (e-cigs) represent a remarkable and increasing proportion of the tobacco product consumption, which can pose an oral health concern. Due to the protein carboxylation , oxidative/carbonyl stress is an important factor in causing the inflammation and the DNA damage. This will lead to the stress-induced premature senescence i.e, a state of irreversible growth arrest which re-enforces chronic inflammation in the gingival epithelium, which as a result may contribute to the pathogenesis of several oral diseases. This article describes the effects of e-cigs with the flavorings and its effects leading to an increased oxidative/carbonyl stress as well as the inflammatory cytokine release in the human periodontal ligament fibroblasts. It also leads to increased levels of cycloxygenase-2 and prostaglandin-E2 which are analogous with the up regulation of the receptor for advanced glycation end products (RAGE) by the e-cig exposure-mediated carbonyl stress in the gingival epithelium/tissue. Furthermore, the e-cigs cause an increased oxidative/carbonyl as well as inflammatory responses and the DNA damage. The present data highlights the pathologic role of the e-cig aerosol and its flavoring to the cells and tissues of oral cavity. Key words: E-cigarettes, ENDS, oral health, periodontal diseases.

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