Journal of AdvancedMedical and Dental Sciences Research

Introduction: Bacterial vaginosis (BV), formerly called non-specific vaginitis, is a polymicrobial disease characterized by reduction in lactobacilli and hydrogen peroxide production, a rise in vaginal pH and overgrowth of BV associated organisms. The present study was conducted to compare metronidazole and tinidazole in cases of Bacterial vaginosis. Materials & Methods: The present study was conducted on 90 patients of Bacterial vaginosis. Patients received either tablet metronidazole 500 mg twice daily for 5 days (Group I) and tablet tinidazole 500 mg once daily + one placebo for 5 days (Group II). In all cases, adverse drug reaction and treatment outcome was assessed. Results: Age group 18-35 years had 14 patients in group I and 17 in group II, 35-50 years had 20 in group I and 18 in group II and >50 years had 11 in group I and 10 in group II. Complete cure was seen in 17 in group II and 14 in group I, partially cure 18 in group II and 20 in group I and not cure in 11 in group I and 10 in group II. The difference was significant (P< 0.05). Nausea/vomiting was seen in 10 in group I and 2 in group II, GI irritation 12 in group and 4 in group II, headache 6 inn group I and 1 in group II and metallic taste 23 in group I and 5 in group II. Conclusion: Authors found that tinidazole was better as compared to metronidazole in cases of Bacterial vaginosis. Key words: Bacterial vaginosis, Metronidazole, Tinidazole