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Volume 8 Issue 1 (January, 2020)

Original Articles

A comparative efficacy of Nystatin and Fluconazole incorporated into tissue conditioner as drug delivery method for Denture stomatitis
Neeraj Kumar, Ayusha Kumari, Vibhash Priyadarshi, Abhijit Kumar, Ravi Shankar Prasad, Bineet Kumar

Background: Denture stomatitis (DS) is a chronic inflammatory condition of the palatal and alveolar mucosa underlying complete or removable dental prostheses. The present study compared efficacy of Nystatin and Fluconazole incorporated into tissue conditioner as drug delivery method for Denture stomatitis. Materials & Methods: The present study was conducted on 40 denture wearers with denture stomatitis of both genders. On the right half, tissue conditioner mixed with 10% fluconazone was applied and on the left half tissue conditioner plus Nystatin 500,000 units was applied. Results: Out of 40 patients, males were 26 and females were 14. The mean C. albicans unit before application on left side of palate was 390.8 and on right side was 380.4. The difference was non- significant (P> 0.05). The mean C. albicans unit after application on left side of palate was 42.6 and on right side was 153.4. The difference was significant (P< 0.05). Conclusion: Authors found that Nystatin as antifungal agent was effective against candida albicans and can be an effective treatment as compared to fluconazole in DS patients. Key words: Candida albicans, Denture stomatitis, Nystatin

 
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