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Volume 7 Issue 12 (December, 2019)

Review Articles

Molecular pathogenesis and therapeutic strategies of Malignant melanoma- A brief Review
Rehmat Parmar

Melanoma is one of the most common and fastest growing cutaneous cancers worldwide. It contributes to 71–80 % of skin cancers deaths. UV radiation, melanotic nevi and sunlight are major risk factors leading to development of melanoma. These risk factors lead to various molecular changes allowing melanoma cells to have a growth and survival advantage over others. Depending on the features of the tumor (location, stage, and genetic profile), the therapeutic options may be surgical resection, chemotherapy, radiotherapy, photodynamic therapy (PDT), immunotherapy, or targeted therapy. In this review, we discuss the various molecular changes associated with cutaneous melanoma and therapies approved or under evaluation for melanoma treatment and relevant research on the molecular mechanisms underlying melanogenesis. Key words: Metastasis, UV radiation, Sunlight, mutation, BRAF, NRAS.

 
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