Background: Cigarette smoking is known to be one of the major causes of various health disorders. The present study was conducted to determine alkaline phosphatase (ALP) level in tobacco users. Materials & Methods: The present study was conducted on 60 patients of both genders. Patients were divided into 4 groups of 15 each depending upon oral lesion and habit of tobacco use. In all subjects, venous blood was obtained to assess alkaline phosphatase level. Results: Out of 60 subjects, males were 40 and females were 20. The mean serum alkaline phosphatase level in group I was 17.3 IU/L, in group II was 8.5 IU/L, in group II was 5.6 IU/L and in group IV was 61.5 IU/L. The difference found to be significant (P< 0.05). Conclusion: Authors found that ALP level was higher in subjects with intraoral lesion and with the habit of smoking/chewing tobacco. ALP may be considered as a reliable noninvasive biomarker in monitoring potentially malignant disorders.
Key words: Alkaline phosphatase, potentially malignant disorders, Smoking.