Journal of AdvancedMedical and Dental Sciences Research

Background: Acute kidney injury (AKI) is characterized by a rapid decline glomerular filtration rate (GFR) and retention of nitrogenous waste products such as blood urea nitrogen (BUN) and creatinine. The present study assessed the cases of AKI in adults. Materials & Methods: The present study was conducted on 102 patients of AKI of both genders. Severities of illness and survival prediction were assessed using acute physiology and chronic health evaluation (APACHE)-IV score. Dialytic support was initiated in patients with anuria, oliguria, serum creatinine >4 mg/ dl, severe acidosis, hyperkalemia and volume overload unresponsive to conservative measures. Results: out of 102 patients, males were 62 and females were 40. Common comorbid conditions was diabetes in 67, hypertension in 54, CAD in 45, cerebrovascular disease in 12 and chronic obstructive pulmonary disease in 19. The difference was significant (P< 0.05). Serum urea level in patients was 145.6 mg/dl, serum creatinine was 5.4 mg/dl, serum sodium was 131 meq/dl and serum potassium was 4.5 meq/dl. Out of 102 patients, 86 survived and 16 died. Conclusion: Authors found AKI has poor prognosis. Common comorbid conditions were diabetes, hypertension, CAD, cerebrovascular disease and chronic obstructive pulmonary disease. Key words: AKI, Hypertension, CAD, cerebrovascular disease