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Volume 7 Issue 8 (August, 2019)

Original Articles

Tacrolimus and clobetasol in management of oral lichen planus- A comparative study
N. Rupa, BVV Srinivas

Background: Oral lichen planus is a common disease of the oral mucosa with a worldwide distribution. The present study was conducted to compare tacrolimus and clobetasol in management of oral lichen planus. Materials & Methods: The present study was conducted on 84 patients of oral lichen planus of both genders. Patients were divided into 2 groups of 42 each. Group I was those who were prescribed tacrolimus (0.1%) cream and group II patients were prescribed clobetasol propionate (0.05%). Patients were examined and recalled regularly to see size of the lesions. VAS score and TC score was compared before treatment, after 3 weeks and 5 weeks. Results: Group I patients received tacrolimus (0.1%) cream and group II patients were prescribed clobetasol propionate (0.05%). Both groups had 42 patients each. Mean VAS score in group I before treatment was 2.1, after 3 weeks was 1.2 and 5 weeks was 0.7. Mean VAS score in group II before treatment was 2.4, after 3 weeks was 1.6 and 5 weeks was 1.0. The difference was significant (P< 0.05). Mean TC score (cm) in group I before treatment was 2.9, after 3 weeks was 1.5 and 5 weeks was 0.8. In group II before treatment was 2.8, after 3 weeks was 1.7 and 5 weeks was 1.2. The difference was significant (P< 0.05). Conclusion: Authors found that tacrolimus 0.1% cream is an effective alternative to topical steroid and can be considered a first-line therapy in OLP. Key words: Clobetasol, tacrolimus, Oral lichen planus

 
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