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Volume 7 Issue 2 (February, 2019)

Original Articles

A comparative study of glimepiride plus metformin versus glibenclamide plus metformin in diabetes mellitus patients
Pratibha Lavania

Background: The present study was conducted to compare the efficacy of glimepiride plus metformin versus glibenclamide plus metformin in patients with type 2 diabetes mellitus patients. Materials & Methods: The present study was conducted on 180 patients of type 2 diabetes mellitus. All were divided into 2 groups of 90 patients each. Group I received combination of glimepiride plus metformin and group II received combination of glibenclamide plus metformin. All were subjected to estimation of fasting plasma glucose, post prandial glucose and BMI before the treatment and 3 and 6 months after treatment. Results: Mean blood glucose level (mg/dl) in group I before treatment was 182.4 and in group II was 178.2, after 3 months was 132.9 in group I and 120.6 in group II, at 6th month was 108.1 and 118.5 in group I and group II respectively. The difference between groups was non- significant (P> 0.05). Mean post prandial blood glucose level (mg/dl) in group I before treatment was 230.4 and in group II was 221.7, after 3 months was 170.2 in group I and 164.5 in group II, at 6th month was 148.3 and 134.7 in group I and group II respectively. The difference between groups was significant (P< 0.05). Conclusion: Authors found that both combination of glimepiride plus metformin and glibenclamide plus metformin found to be equally effective in patients with type 2 diabetes mellitus. Key words: Diabetes mellitus, Glucose, Metformin

 
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