Background: Breast cancer is common in females and its treatment with chemotherapeutic agents is not free from hematological toxicity. There are many agents to ameliorate this toxicity. Aim and Objective: The present prospective, randomized, open label, comparative study was conducted in a tertiary care hospital to evaluate the effect of wheatgrass on hematological toxicity in breast cancer patients. Material and Methods: The standard anticancer therapy 5-Flourouracil (500mg/m2), Adriamycin (50mg/m2)/Epirubicin (100 mg/m2), Cyclophosphamide (500mg/m2) or Doxorubicin (60mg/m2) and Cyclophosphamide (600mg/m2) plus GCSF(300µgm). Group A served as control arm and Group B as test arm which received wheat grass two tablets (wheat grass ingredient 500 mg) three times a day beside the anticancer treatment. Results: The deterioration of hematological parameters (Haemoglobin, Platelet Count) produced in Ca breast patients by anti cancer therapy has been effectively prevented by the adding WG. Moreover, in the WG group there were less number of blood transfusions requirement compared to the control arm. Conclusion: The study concluded that wheat grass is effective in preventing the deterioration of hemoglobin and platelet count and curtailed the number of transfusions needed by patients of breast cancer on anticancer treatment.
Key words: Breast Cancer, Chemotherapy, Hematotoxicity, Wheat grass
Received: 8 July, 2018 Revised: 12 August, 2019 Accepted: 15 August, 2019
Corresponding Author: Dr. Neelam Rani, Demonstrator, Dept. of Pharmacology, GMC, Jammu, India
This article may be cited as: Rani N, Khajuria V, Tandon VR, Sharma R. Evaluation of Wheat Grass in Preventing Haematological Toxicity Related to Chemotherapy in Breast Cancer Patients. J Adv Med Dent Scie Res 2019;7(9):85-89.