Background: Gallstone disease produces diverse histopathological changes in gallbladder mucosa-namely, acute inflammation, chronic Inflammation, granulomatous inflammation, hyperplasia, cholesterolosis, dysplasia and carcinoma. Under the light of above evidence; we planned the present study to assess gall bladder mucosal changes in gall stone patients. Materials & methods: A total of 50 gallstone patients were enrolled in the present study. Laparoscopic cholecystectomy was performed in all the patients and gallbladder mucosal samples were sent for histopathologic analysis. The tissue was properly sampled and processed by routine histological techniques for paraffin embedding and sectioning at 4 micron thickness. Four sections including entire wall were obtained: two from body, one each from fundus and neck of the gall bladder. Additional sections were taken from abnormal mucosa.
Results: Among 50 patients in the present study, chronic cholecystitis was the diagnosis in 40 patients (80 percent of the patients), while pre-invasive and invasive diagnosis was seen in 8 patients (16 percent of the patients) and 2 patients (4 percent of the patients) respectively. Mean size of stone in the cholecystitis patients was 0.68 cm, while mean size of stone in pre-invasive and invasive patients was found to be 1.19 cm and 3.98 cm. Significant results were obtained while assessing the correlation of size of gallstones with gallbladder mucosal response. Conclusion: dentification of premalignant modifications in the morphologic background of chronic cholecystitis is an argument in favor of the metaplasia-dysplasia-neoplasia sequence. However; further studies are recommended.
Key words: Gallbladder, Invasive, Mucosal
Received: 15 April, 2019 Revised: 25 July 2019 Accepted: 26 July 2019
Corresponding Author: Dr. Pramila Gupta, Department of Pathology, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India
This article may be cited as: Gupta P. Assessment of Gall Bladder Mucosal Changes in Gall Stone Patients. J Adv Med Dent Scie Res 2019;7(8): 112-114.