Journal of AdvancedMedical and Dental Sciences Research

Background: Oral Submucous Fibrosis (OSMF) is a chronic progressive debilitating disease of the oral mucosa involving the oropharynx. OSMF is predominantly seen in people of South and Southeast Asia – India, Bangladesh, Sri Lanka, Pakistan, Taiwan, Southern China, etc., where chewing of betel quid, areca nut or its flavored formulations is frequently practiced.Lycopene has some beneficial effects in the treatment of certain diseases of oral cavity including oral cancer and precancerous lesions; lycopene does not have the pro-vitamin A activityand its various benefits on human health. Aim of the study: To assess the efficacy of Lycopene in combination with vitamin E in management of OSMF. Materials and methods: The study was conducted in the Department of Dentistry of Shridevi Institute of Medical science and research hospital, Tumakuru, Karnataka. A total of 50 patients, who were confirmed histologically and diagnostically wit OSMF were included in the study. An informed written consent was obtained from each patient after explaining them the procedure and aim of the study.The patients were randomly grouped into two groups, Group A and Group B. Patients in Group A were treated with Lycopene 8 mg, whereas, patients in Group B were treated with Lycopene 8 mg + Vit. E (400 IU).At follow-up visits, patients were assessed for inter-incisal distance in mm and burning sensation by visual analog scale from 1 to 10. Results: A total of 50 patients with OSMF were included in the study.The mean mouth opening after the completion of treatment in Group A was 5.12+1.65 mm and in Group B was 6.87+2.01 mm. The results on comparing were found to be statistically significant. (p<0.05) In group A, burning sensation was still present after the treatment in 3 patients and was absent in 22 patients. In group B, burning sensation was still present after the treatment in one patient and was absent in 24 patients. The results on comparison were found to be statistically significant. Conclusion:  From the results of the present study, we conclude that Lycopene 8 mg with Vitamin E is highly effective treatment for OSMF patients.
Key words: Lycopene, OSMF, Premalignant, Vitamin E.

Received: 10 May, 2019                            Revised:  28 May 2019                             Accepted: 29 May 2019

Corresponding author: Dr. Shubha Kumaraswamy, Senior lecturer, Dept of Oral Pathology and Microbiology, Sri Siddhartha Dental College, Agalkote BH road Tumkur, Karnataka, India

This article may be cited as: K. Kumar V , LN Akshatha, Kumaraswamy S, H G Suhas, Topajiche SS. Efficacy of Lycopene in combination with vitamin E in management of OSMF. J Adv Med Dent Scie Res 2019;7(6): 6-9.