Journal of AdvancedMedical and Dental Sciences Research

Background: Premedication should yield a patient who is calm, free of anxiety and pain. The present study was conducted to compare the efficacy of midazolam with clonidine as a premedication agent. Materials & methods: This study was conducted in department of Anaesthesia. It consisted of 60 patients with ASA grade I and II. Patients were divided into 2 groups of 30 each. Group I received 4mcg/kg of oral clonidine and group II received 0.5mg/kg oral midazolam as a premedication about I hour before induction of anaesthesia. Drug acceptance and anxiety score was recorded. Results:  Group I, score 1 was seen in 14, 2 in 10 and 3 in 6 children. In group II, score 1 was seen in 10, 2 in 12 and 3 in 8 children. The difference was significant (P< 0.05). The mean sedation score in group I was 2.8 and in group II was 1.2. The difference was significant (P< 0.05). Conclusion: Authors found that there was better sedation and drug acceptance score with clonidine which could be used as an alternative to midazolam as pre- anesthetic agent.
Key words: Clonidine, Drug acceptance, Sedation

Received: 18 February, 2019                           Revised: 28 March, 2019                               Accepted: 29 March, 2019

Corresponding author: Dr. Meenakshi . K. Moorthy, Assistant professor , Department of Anaesthesia, Hind institute of Medical Sciences, Ataria, Sitapur, Uttar Pradesh, India

This article may be cited as: Moorthy MK. Efficacy of Clonidine & Midazolam as Premedication Agent- A Comparative Study. J Adv Med Dent Scie Res 2019;7(4): 59-61.