Journal of AdvancedMedical and Dental Sciences Research

Background: AMI is one of the leading causes of morbidity and mortality across the world. Zinc is important trace element and has important role as antioxidant element and cell membrane stability and there is paucity of information in the literature in this regard ;so this study was done to assess serum level of zinc in cases of AMI in Khartoum state. Objective: The aim of this study is to assess the level of serum zinc in patients with acute myocardial infarction an its correlation with cardiac markers. Materials and Methods: this study was performed at Sudan Center for Heart disease in Khartoum state , Sudan, during the period from February to October 2017.50 sample were collected from admitted patients with acute myocardial infarction as test group, in addition to other 50 sample from healthy volunteer sex and age matched as control group . the levels of serum zinc element were determined in both group by atomic absorption spectroscopy. Results: serum zinc levels were significantly lower in patients with acute myocardial infarction when compared with control group (0.351±0.08 versus 0.531±0.09, p = 0.000) in table 1.According to age groups of the test group there is insignificant difference in serum zinc and troponin T levels ( P > 0.05) .Whereas across duration of infarction serum zinc level is significantly decreased in day 1(0.35 ± 0.08 versus 0.53 ±0.09, p = 0.000), day 2 (0.31± 0.05 versus 0.53 ±0.09, p = 0.000), and started to increase in day 3( 0.39 ± 0.09 versus 0.53 ±0.09, p = 0.01), and serum zinc fluctuated to normal level in day 10 (0.50 ± 0.06 versus 0.53 ±0.09, p = 0.91) . The study observed insignificantly inversely correlated between serum zinc level with AST and LDH ( P > 0.05).But significant inversely correlation with with serum CKMB and troponin T(r= - 0.28. p= 0.03and -r = 0.34,p = 0.001respectively). Conclusion: The study revealed reduced serum zinc level in patients with acute myocardial infarction, and significantly inversely correlated with cardiac markers CKMB and troponin T. Key words: Acute myocardial infarction; AST, LDH CKMB, Cardiac Troponin T, Serum Zinc.