Background and Aim: Surgical removal of mandibular third molar is a routine procedure in surgery department. Painless removal of third molar is desired by patients. The present study was conducted to determine efficacy of ketamine on post-operative symptoms occurring on impacted mandibular third molar surgery. Materials & Methods: The present study was conducted on 30 patients with bilateral impacted mandibular third molars. They were divided into 2 groups. Group I (15) received lignocaine and group II received lignocaine along with ketamine. 5ml of 2% lignocaine with 1:150, 000 adrenaline was given in group I and 5ml of 2% lignocaine with 1:150, 000 adrenaline and 0.2mg/kg of ketamine was inserted in group II. Patients were recalled 1st postoperative day, 4th day and 7th day for assessment of symptoms such as pain and mouth opening. Statistical Analysis and Results: All the results were assessed and analyzed by SPSS software. On day one, VAS pain score in group I was 5.8± 1.4 and in group II was 4.2± 1.5. On day four, it was 4.0± 1.6 and 2.9± 1.8 respectively in both groups and on day &, it was 2.1± 1.2 in group I and 0.6± 1.3 in group II. The difference was significant (P< 0.05). All other data and results were correlated clinically and evaluated for levels of significances. Conclusion: Ketamine found to be a useful agent in management of post- operative pain in surgical extraction of impacted mandibular third molars. However, there was no difference in mouth opening in both groups.
Key Words: Ketamine, Lignocaine, Mandibular.