Leucine-rich repeat-containing G protein coupled receptor 5 (LGR5) is a biomarker for cancer stem cell which has been responsible for the cancer development and progression. After the validation of LGR 5 as a marker of intestinal stem cells, the field has become more apparent and led to many new avenues of research. Recently, studies are also supported that LGR5 is overexpressed in diverse types of human cancers, including colorectal, gastric, esophageal, hepatocellular carcinomas and pancreatic adenocarcinoma. This emerging technology opens new possibilities of using cultured adult stem cells for drug development, disease modeling, gene therapy and regenerative medicine. This review describes the expression of LGR5 stem cells in HNSCC and summarizes subsequent progress, promises, unresolved issues, and challenges of the field.
Key words: LGR5, oral cancer, oral dysplasia.
Received: 20 October 2018 Accepted: 25 October 2018
Corresponding author: Dr. Sabitha S MDS., 19-3D; ARRS apartment, Greenways road, Fairlands, Salem – 636016
This article may be cited as: S Sabitha, Mohan J, Nirmal RM, P Vasanthan, JJ Sathiya. Significant Role of LGR-5 in Oral Cancer and Oral Dysplasia- A Review. J Adv Med Dent Scie Res 2018;6(10):30-36.