Volume 6 Issue 9 (September, 2018)

Original Articles

Assessment of Serum Zinc among Sudanese Patients with Acute Myocardial Infarction
Hozifa abed albage yousif, Abdelmula M. Abdalla

Background: AMI is one of the leading causes of morbidity and mortality across the world. Zinc  is important trace element and has important role as antioxidant element and cell membrane stability and there is paucity of  information in the literature in this regard ;so this study was done to assess serum level of zinc in cases of AMI in Khartoum state. Objective: The aim of this  study is to assess the level of serum zinc in patients with acute myocardial infarction an its   correlation with cardiac markers. Materials and Methods: this study was performed at Sudan  Center  for Heart disease in Khartoum state , Sudan, during the period from February  to October 2017.50 sample were collected from admitted patients with acute myocardial infarction as test group, in addition to other  50 sample from healthy volunteer sex and age matched as control group . the levels of serum  zinc element were determined in both group by atomic absorption spectroscopy.   Results: serum zinc  levels were significantly lower in patients with acute myocardial infarction when compared with control group (0.351±0.08 versus 0.531±0.09, p = 0.000) in table 1.According to age groups of the test group there is insignificant difference in  serum zinc and troponin T levels ( P > 0.05) .Whereas across duration of infarction  serum zinc level  is significantly decreased in day 1(0.35 ± 0.08 versus 0.53 ±0.09, p = 0.000), day 2 (0.31± 0.05 versus 0.53 ±0.09, p = 0.000),  and started to increase in day 3(  0.39 ± 0.09 versus 0.53 ±0.09, p = 0.01), and serum zinc fluctuated to normal level in day 10 (0.50 ± 0.06 versus 0.53 ±0.09, p = 0.91) . The study observed insignificantly inversely correlated between serum  zinc level with  AST and LDH (  P > 0.05).But significant  inversely correlation with with serum CKMB and  troponin T(r= - 0.28. p= 0.03and  -r =  0.34,p = 0.001respectively). Conclusion: The study revealed reduced serum zinc level  in patients with acute myocardial infarction, and significantly inversely correlated with cardiac markers  CKMB and troponin T.
Key words: Acute myocardial infarction; AST, LDH CKMB, Cardiac Troponin T, Serum Zinc.

Corresponding Author: Abdelmula M. Abdalla, Faculty of Medical Laboratory Science, Department of Clinical Chemistry, Alneelain University, Khartoum state, Sudan.

This article may be cited as: Yousif HA,   Abdalla AM. Assessment of Serum Zinc among Sudanese Patients with Acute Myocardial Infarction. J Adv Med Dent Scie Res 2018;6(9):55-58.

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