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Volume 2 Issue 4 (October- December, 2014)

Original Articles

Efficacy of combination of Glimepiride plus Metformin versus Glibenclamide plus Metformin in patients with type 2 Diabetes Mellitus- A Comparative Study
Vinita Bharti

Background: Diabetes mellitus is a chronic condition and is characterized by hyperglycemia resulting from defect in insulin secretion, insulin action or both. The present study was conducted to compare the efficacy of glimepiride plus metformin versus glibenclamide plus metformin in patients with type 2 diabetes mellitus patients. Materials & Methods: The present study was conducted on 280 patients (males- 150, females- 130) of type 2 diabetes mellitus. All were divided into 2 groups of 140 patients each. Group I received combination of glimepiride plus metformin and group II received combination of glibenclamide plus metformin. All were subjected to estimation of HbA1C, fasting plasma glucose, post prandial glucose and BMI before the treatment and 3 and 6 months after treatment. Results: Mean age in group I patients was 45.2 years and in group II was 46.3 years. Duration of illness was 12.5 years in group I and 16.7 years in group II. Mean blood glucose level (mg/dl) in group I before treatment was 180.4 and in group II was 176.2, after 3 months was 130.8 in group I and 128.4 in group II, at 6th month was 106.2 and 110.2 in group I and group II respectively. The difference between groups was non- significant (P> 0.05) while within the group was significant (P< 0.05). Mean post prandial blood glucose level (mg/dl) in group I before treatment was 224.4 and in group II was 228.2, after 3 months was 171.2 in group I and 168.4 in group II, at 6th month was 142.2 and 138.2 in group I and group II respectively. The difference between groups was non- significant (P> 0.05) while within the group was significant (P< 0.05). HbA1C level % was 8.1 in group I and 8.2 in group before treatment, 7.2 and 7.4 after 3 months and 6.5 and 6.1 after 6 months in group I and group II respectively. The difference was significant (P< 0.05). Conclusion: Both combination of glimepiride plus metformin and glibenclamide plus metformin found to be equally effective in patients with type 2 diabetes mellitus.
Key words: Diabetes mellitus, Glimepiride, Glibenclamide, Metformin

Corresponding author: Dr. Vinita Bharti, Assistant Professor, Department of Pharmacology, Integral Institute of Medical Science & Research Lucknow, U.P., India
This article may be cited as:  Bharti V. Efficacy of combination of Glimepiride plus Metformin versus Glibenclamide plus Metformin in patients with type 2 Diabetes Mellitus- A Comparative Study. J Adv Med Dent Scie Res 2014;2(4):184-186.


 
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