Background: The odontogenic keratocyst (OKC) is known to have a more aggressive biologic behaviour than other cysts of jaw. Podoplanin which is frequently used as a lymphatic endothelial marker in OSCCs has recently been found to play a possible role in odontogenic tumorigenesis also. Hence; we planned the present study to assess the role of podoplanin in OKC. Materials & methods: The present study included evaluation a total of 20 OKC specimens and 20 dental follicle specimens (Control). The tissue sections were stained; one with hematoxylin and eosin (H & E) stain and another with Podoplanin Antihuman antibody by immunohistochemical methods. All the results were analyzed by SPSS software. Results: Significant results were obtained while comparing the mean staining final score in between OKCs specimens and dental follicle specimens. Conclusion: Podoplanin influences the proliferative activity of basal and suprabasal cells in the epithelial lining of OKCs. However; future studies are recommended.
Key words: Dental follicle, Odontogenic keratocyst, Podoplanin