Background: The outcome of an abdominal infection depends on the complex interaction of many different factors and the success obtained with the early institution of specific therapeutic procedures. It also depends upon the exact recognition of the seriousness of the diseases and an accurate assessment and classification of the patient`s risks.The present study was undertaken to evaluate complications and outcome of patients with perforation peritonitis using APACHE II scoring system. Material and Methods: The present study was commenced among 50 patients who underwent laparotomy for acute peritonitis due to gastrointestinal perforation, after diagnostic confirmation at Rajindra Hospital, Patiala.All patients were evaluated clinically, haematological and biochemical investigations were carried out. X-Ray Abdomen Erect and supine, Plain X-ray chest-PA View and ultrasound whole abdomen were done. The acute physiological parameter of APACHE II were assessed and recorded at the admission point preoperatively and were scored in accordance with the APACHE II chart. Results: 65 % of patients had hospital stay of 10-12 days and on the other hand 30 % had 13-15 days. I, mean APACHE II score with highly significant P-Value of 0.001. Out of 50 patients, total 10 patients died, in which 4 patients each with duodenal and ileal perforations and 2 with gastric perforation. The mean APACHE II score in patients who died was 21.50±5.082 S.D with highly significant P. Value <0.001Conclusion:Cases of peritonitis carry a high mortality which can be reduced by early diagnosis, risk stratification, appropriate treatment based on risk score. Delayed presentation which has important effect on both mortality and morbidity is beyond our control. Only adequate Health education, proper referral mechanism can help to overcome this factor
Key words: Peritonitis; Mortality; Complication.